We thank all the participants of the 2019 Tiselius symposium (the 4th in the order) for your contribution to making the meeting a great success. We hope to welcome you back to the 5th Tiselius symposium in 2021.

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Tiselius symposium 28/8 2019

PROGRAMME

8:30-9:00 Registration

SESSION 1 – Opening session (chair: Mikael Widersten)

9:00-9:10 Welcome

Eva Åkesson (Uppsala University vice-chancellor, UU, Sweden)

9:10-9:30 Tiselius and the Swedish post-war research policy

Anna Tunlid (UU, Sweden)

9:30-10:15     Molecular dynamics of ligand-gated ion channels from signal transduction to allosteric modulation: implications for drug discovery

Jean-Pierre Changeux (Institut Pasteur & College de France, Paris, France)

10:15-10:45     Coffee break and poster session

SESSION 2 – Protein stability and degradation (Chair: Ylva Ivarsson)

10:45-11:15     Allosteric regulation of ubiquitin signals

Helen Walden (University of Glasgow, UK)

11:15-11:45 Protein Stability in Drug Discovery and Molecular Biology

Mikhail Savitski (EMBL Heidelberg, Germany)

11:45-12:00     Advanced tools for detailed structural and functional analysis of protease cleavage specificity

Lars Hellman (UU, Sweden)

12:00-12:15     Insights in structural determinants of β2-microglobulin stability

Benedetta Maria Sala (KTH, Sweden)

12:15-13.30     Mingle lunch and poster session

SESSION 3 – Protein structure & function (Chair: Erik Marklund)

13:30-14:00     The moving boundary of protein separation: from electrophoresis of Tiselius to classification by cryo-EM

Alexey Amunts (SU, Sweden)

14:00-14:30     Biomimicry of Nature´s high performance fiber: How to spin artificial spider silk

Anna Rising (SLU/KI, Sweden)

14:30-14:45     Discovery of fragments targeting dynamic proteins using Second-Harmonic Generation

Edward FitzGerald (UU, Sweden)

14:45-15:00     Computational approach to substrate promiscuity: a case study of selected phospholipase and lipase enzymes

Aleksandra Maršavelski (University of Zagreb, Croatia)

15:00-15:15      Molecular design of new functions in the GSTome

Bengt Mannervik (SU, Sweden)

15:15-15:45     Coffee break and poster session

SESSION 4 –  Closing session (Chair: Lynn Kamerlin)

15:45-16:30     Protein self-association, dynamics and function

Shoshana Wodak (VIB-VUB center for structural Biology, Brussels, Belgium)

16:30-16:55     How to raise a next-generation Tiselius?

Panel discussion  

16:55-17:00     Closing remarks

Helena Danielson (UU, Sweden)