We thank all the participants of the 2019 Tiselius symposium (the 4th in the order) for your contribution to making the meeting a great success. We hope to welcome you back to the 5th Tiselius symposium in 2021.
Opening lecture by Jean-Pierre Changeux.


Tiselius symposium 28/8 2019
PROGRAMME
8:30-9:00 Registration
SESSION 1 – Opening session (chair: Mikael Widersten)
9:00-9:10 Welcome
Eva Åkesson (Uppsala University vice-chancellor, UU, Sweden)
9:10-9:30 Tiselius and the Swedish post-war research policy
Anna Tunlid (UU, Sweden)
9:30-10:15 Molecular dynamics of ligand-gated ion channels from signal transduction to allosteric modulation: implications for drug discovery
Jean-Pierre Changeux (Institut Pasteur & College de France, Paris, France)
10:15-10:45 Coffee break and poster session
SESSION 2 – Protein stability and degradation (Chair: Ylva Ivarsson)
10:45-11:15 Allosteric regulation of ubiquitin signals
Helen Walden (University of Glasgow, UK)
11:15-11:45 Protein Stability in Drug Discovery and Molecular Biology
Mikhail Savitski (EMBL Heidelberg, Germany)
11:45-12:00 Advanced tools for detailed structural and functional analysis of protease cleavage specificity
Lars Hellman (UU, Sweden)
12:00-12:15 Insights in structural determinants of β2-microglobulin stability
Benedetta Maria Sala (KTH, Sweden)
12:15-13.30 Mingle lunch and poster session
SESSION 3 – Protein structure & function (Chair: Erik Marklund)
13:30-14:00 The moving boundary of protein separation: from electrophoresis of Tiselius to classification by cryo-EM
Alexey Amunts (SU, Sweden)
14:00-14:30 Biomimicry of Nature´s high performance fiber: How to spin artificial spider silk
Anna Rising (SLU/KI, Sweden)
14:30-14:45 Discovery of fragments targeting dynamic proteins using Second-Harmonic Generation
Edward FitzGerald (UU, Sweden)
14:45-15:00 Computational approach to substrate promiscuity: a case study of selected phospholipase and lipase enzymes
Aleksandra Maršavelski (University of Zagreb, Croatia)
15:00-15:15 Molecular design of new functions in the GSTome
Bengt Mannervik (SU, Sweden)
15:15-15:45 Coffee break and poster session
SESSION 4 – Closing session (Chair: Lynn Kamerlin)
15:45-16:30 Protein self-association, dynamics and function
Shoshana Wodak (VIB-VUB center for structural Biology, Brussels, Belgium)
16:30-16:55 How to raise a next-generation Tiselius?
Panel discussion
16:55-17:00 Closing remarks
Helena Danielson (UU, Sweden)